While it's true that Singapore is a small country in terms of geographic size and population, it doesn't necessarily preclude the possibility of building a global business empire. However, there are certainly unique challenges and opportunities that businesses based in Singapore need to navigate.

1. Limited Domestic Market: Singapore's small population means that the domestic market is limited. A brand like Oreo, which sells a mass-market consumer product, thrives on having a large base of potential consumers. Singapore's market is not large enough for a business to reach the same scale domestically. Opportunity: However, Singapore's strategic location in Southeast Asia, a region with a rapidly growing middle class and over 650 million people, means that businesses based there have significant opportunities for regional expansion.
2. High Costs: Singapore has a high cost of living and high business costs, including rents and wages. These could potentially make it more challenging for a business to achieve profitability and scale. Opportunity: On the other hand, Singapore's strong rule of law, efficient bureaucracy, and pro-business policies can help businesses operate smoothly and effectively.
3. Lack of Natural Resources: Unlike countries that have abundant natural resources, Singapore has to import most of its raw materials, which could increase costs for some types of businesses. Opportunity: However, Singapore's excellent infrastructure, logistics capabilities, and free trade agreements can help businesses efficiently import and export goods.
4. Diverse Market Preferences: Singapore's multicultural society means businesses need to cater to a wide range of tastes and preferences, which can be a challenge for a product like Oreo that thrives on mass appeal. Opportunity: This diversity also gives Singaporean companies experience in catering to a multicultural market, which can be an advantage when expanding globally.

It's also worth noting that there are successful multinational corporations based in Singapore. For example, Flex Ltd, a global electronics manufacturing services company, and Wilmar International, a leading agribusiness group, have both built substantial operations around the world from their bases in Singapore.

In conclusion, while there are challenges to building a business empire like Oreo from a small country like Singapore, there are also significant opportunities. With the right business model, strategy, and execution, it's entirely possible for a Singapore-based company to achieve global success.